Benjamin Harrison's great-grandfather, Benjamin Harrison V, was born in Berkeley, Virginia, in 1726. He attended William and Mary College in Williamsburg. In 1764, when the House defied the Royal Governor and passed the Stamp Act Resolutions, the Governor tried to bribe Harrison with an appointment to the executive council. He refused the appointment and instead declared a devotion to republican principles. Elected to the Continental Congress in 1774, he was one of a party of representatives who, the following year, attended General Washington in Cambridge to plan the future of the American Army. He had reservations about the Constitution, a document which seemed to promote kingly power while increasing the mistrust between southern and northern countrymen. A slave owner himself, his great-grandson would be a Union soldier 80 years later. He was elected Governor of the State of Virginia in 1782. He retired from the Governor's office after five years of service. He died in 1791 at the age of 65.
William Henry Harrison, Benjamin Harrison's grandfather, obtained a commission as ensign in the First Infantry of the Regular Army, and headed to the Northwest. In the campaign against the Indians, Harrison served as aide-de-camp to General "Mad Anthony" Wayne at the Battle of Fallen Timbers, which opened most of the Ohio area to settlement. In 1798, he became Secretary of the Northwest Territory. In 1801, he became Governor of the Indiana Territory, serving 12 years. The Battle of Tippecanoe, upon which Harrison's fame was to rest, disrupted Tecumseh's confederacy but failed to diminish Indian raids. In the War of 1812, Harrison won more military laurels when he was given the command of the Army in the Northwest with the rank of Major General. The Whigs nominated him for president in 1840. He won, but before he had been in office a month, he developed pneumonia and died.
John Scott Harrison, Benjamin's father, was born in Vincennes, Indiana, October 4, 1804. He managed affairs at North Bend, Ohio, while his father was away. From 1853 to 1857, he served in the United States Congress in the House of Representatives as a Whig from Ohio. This was a tremulous time, and John Scott stood firm on issues like the Kansas-Nebraska bill. He believed that it was necessary for mutual forbearance and compromise, in order that the Union might be saved. John Scott retired from politics and return to his estate at North Bend. He died on May 25, 1878.
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Harrison was deeply devoted to his wife Caroline. As she was dying of tuberculosis in the fall of 1892, Harrison relinquished all effort towards his re-election campaign. He did not neglect his presidential duties, but refused all invitations to speak or campaign on his own behalf, so that he might spend all his remaining time beside her deathbed. Caroline died October 25, two weeks before the election – Benjamin was so grief-stricken that he could not even bestir himself to return to Indianapolis to vote for himself on Election Day. There was no such thing as an absentee ballot at that time. According to an eavesdropping servant, on her deathbed Caroline was supposed to have made her husband promise to remarry, saying, "Ben, you can't take care of yourself."